The Role of IgG Subclass in Antibody-Mediated

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The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae

  • Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
  • However, the characteristics by which these antibodies (Abs) function, such as the role of antibody subclass, must be determined before such modalities can be carried from the bench to the bedside. We performed a subclass switch on anticapsular monoclonal murine IgG3 (mIgG3) hybridomas and identified and purified a murine IgG1 (mIgG1) hybridoma line through sib selection. We then compared the ability of the mIgG1 and mIgG3 antibodies to control CR-Kp sequence type 258 (ST258) infection both in vitro and in vivo.
  • We found by enzyme-limited immunosorbent assay (ELISA) and flow cytometry that mIgG3 has superior binding to the CR-Kp capsular polysaccharide (CPS) and superior agglutinating ability compared to mIgG1 The mIgG3 also, predictably, had better complement-mediated serum bactericidal activity than the mIgG1 and also promoted neutrophil-mediated killing at concentrations lower than that of the mIgG1 In contrast, the mIgG1 had marginally better activity in improving macrophage-mediated phagocytosis.
  • Comparing their activities in a pulmonary infection model with wild-type as well as neutropenic mice, both antibodies reduced organ burden in a nonlethal challenge, regardless of neutrophil status, with mIgG1 having the highest overall burden reduction in both scenarios.
  • However, at a lethal inoculum, both antibodies showed reduced efficacy in neutropenic mice, with mIgG3 retaining the most activity. These findings suggest the viability of monoclonal Ab adjunctive therapy in neutropenic patients that cannot mount their own immune response, while also providing some insight into the relative contributions of immune mediators in CR-Kp protection.IMPORTANCE Carbapenem-resistant Klebsiella pneumoniae is an urgent public health threat that causes life-threatening infections in immunocompromised hosts.
  • Its resistance to nearly all antibiotics necessitates novel strategies to treat it, including the use of monoclonal antibodies. Monoclonal antibodies are emerging as important adjuncts to traditional pharmaceuticals, and studying how they protect against specific bacteria such as Klebsiella pneumoniae is crucial to their development as effective therapies.
  • Antibody subclass is often overlooked but is a major factor in how an antibody interacts with other mediators of immunity. This paper is the first to examine how the subclass of anticapsular monoclonal antibodies can affect efficacy against CR-Kp Additionally, this work sheds light on the viability of monoclonal antibody therapy in neutropenic patients, who are most vulnerable to CR-Kp infection.
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Human Galectin-1

MBS691972-001mg 0.01mg
EUR 300

Human Galectin-1

MBS691972-005mg 0.05mg
EUR 450

Human Galectin-1

MBS691972-5x005mg 5x0.05mg
EUR 1725

Galectin-1, Human

E34M148H 5 μg
EUR 155

Galectin-1 Human

GWB-DAB7E1 0.05 mg Ask for price

Galectin-1, Human

MBS8575305-0005mg 0.005mg
EUR 245

Galectin-1, Human

MBS8575305-5x0005mg 5x0.005mg
EUR 940

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-006mL 0.06mL
EUR 250

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-012mL 0.12mL
EUR 370

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-02mL 0.2mL
EUR 550

Human Galectin-1 (Gal-1) Antibody

30005-05111 150 ug
EUR 215

Human Galectin( Galectin) Elisa Kit

EK711568 96 Wells
EUR 0.18

RABBIT ANTI HUMAN GALECTIN-3:Biotin

MBS222930-005mg 0.05mg
EUR 655

RABBIT ANTI HUMAN GALECTIN-3:Biotin

MBS222930-5x005mg 5x0.05mg
EUR 2780

Rabbit Anti-Human Galectin-1

102-PA131 100ug
EUR 240

Anti-Human Galectin-1 Antibody

102-P131 100 µg
EUR 245.7
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and anti-inflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

Anti-Human Galectin-1 Antibody

102-PA131AG 50 µg
EUR 157.5
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

Anti-Human Galectin-1 Antibody

102-PA131S 100 µg
EUR 126
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

human anti-human galectin-3 mAb(2D)

E4A09H10-2D 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(5F)

E4A09H10-5F 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(A5)

E4A09H10-A5 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(G2)

E4A09H10-G2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(H3)

E4A09H10-H3 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(T1)

E4A09H10-T1 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Galectin-1 (LGALS1)

1-CSB-EP012882HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Galectin-1 (LGALS1)

1-CSB-EP012882HUb1
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  • 100ug
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  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-006mL 0.06mL
EUR 250

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-012mL 0.12mL
EUR 370

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-02mL 0.2mL
EUR 550

human anti-human galectin-3 mAb(N13)

E4A09H10-N13 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Galectin-1 Protein

PRP1033-100g 100 µg
EUR 309

Human Galectin-1 Protein

PRP1033-1mg 1 mg
EUR 1099

Human Galectin-1 Protein

PRP1033-20g 20 µg
EUR 79

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-006mL 0.06mL
EUR 250

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-012mL 0.12mL
EUR 370

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-02mL 0.2mL
EUR 550

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-006mL 0.06mL
EUR 250

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-012mL 0.12mL
EUR 370

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-02mL 0.2mL
EUR 550

Anti Human Galectin-3 Polyclonal Antibody

KH040 each
EUR 778.8
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Human Galectin-3(Galectin-3)ELISA Kit

YLA0216HU-48T 48T Ask for price

Human Galectin-3(Galectin-3)ELISA Kit

YLA0216HU-96T 96T Ask for price

Recombinant Human Galectin-1

7-00427 10µg Ask for price

Recombinant Human Galectin-1

7-00428 50µg Ask for price

Recombinant Human Galectin-1

7-00429 1mg Ask for price

Recombinant Human Galectin-1

AP60482 100ug
EUR 449

Recombinant Human Galectin-1

HEOPP-0710 10ug Ask for price

RECOMBINANT HUMAN GALECTIN-1

GWB-BEA2B0 0.05 mg Ask for price

Recombinant Human Galectin-1

cyt-544-10g 10µg
EUR 60

Recombinant Human Galectin-1

cyt-544-1mg 1mg
EUR 1350

Recombinant Human Galectin-1

cyt-544-50g 50µg
EUR 145

Recombinant Human Galectin-1

MBS143303-001mg 0.01mg
EUR 240

Recombinant Human Galectin-1

MBS143303-005mg 0.05mg
EUR 310

Recombinant Human Galectin-1

MBS143303-1mg 1mg
EUR 1515

Recombinant Human Galectin-1

MBS143303-5x1mg 5x1mg
EUR 6485

RECOMBINANT HUMAN GALECTIN-1

MBS232407-005mg 0.05mg
EUR 500

RECOMBINANT HUMAN GALECTIN-1

MBS232407-5x005mg 5x0.05mg
EUR 2070

Recombinant Human Galectin-1

P1229-.01 10ug
EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

P1229-.1 10X10ug
EUR 450.4
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

P1229-.5 50X10ug
EUR 1010.4
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

MBS9420409-002mg 0.02mg
EUR 285

Recombinant Human Galectin-1

MBS9420409-01mg 0.1mg
EUR 470

Recombinant Human Galectin-1

MBS9420409-1mg 1mg
EUR 1785

Recombinant Human Galectin-1

MBS9420409-5x1mg 5x1mg
EUR 7885

Recombinant Human Galectin-1

MBS966052-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Galectin-1

MBS966052-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Galectin-1

MBS966052-1mgEColi 1mg(E-Coli)
EUR 1425

Recombinant Human Galectin-1

MBS966052-5x1mgEColi 5x1mg(E-Coli)
EUR 6215

anti- Galectin-1 antibody

FNab03314 100µg
EUR 606.3
Description: Antibody raised against Galectin-1

anti- Galectin-1 antibody

FNab03315 100µg
EUR 658.5
Description: Antibody raised against Galectin-1

Anti- Galectin-1 Antibody

GWB-6F6392 0.1 mg Ask for price

Human Galectin 1 Protein

20-abx066725
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  • 100 ug
  • 10 ug
  • 1 mg
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Human Galectin-1 Antibody Pair Set

ABPR-ZB244 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human Galectin-1

Galectin-1, human recombinant

4648-10 each
EUR 170.4

Galectin-1, human recombinant

4648-1000 each
EUR 1977.6

Galectin-1, human recombinant

4648-50 each
EUR 314.4

Galectin-1 Human Recombinant

rAP-2252 Inquiry Ask for price

Galectin-1 (human), (recombinant)

MBS567229-01mg 0.1mg
EUR 750

Galectin-1 (human), (recombinant)

MBS567229-5x01mg 5x0.1mg
EUR 3320

Anti-Human Galectin-1 Azide Free

MBS335796-02mg 0.2mg
EUR 290

Anti-Human Galectin-1 Azide Free

MBS335796-05mg 0.5mg
EUR 555

Anti-Human Galectin-1 Azide Free

MBS335796-5x05mg 5x0.5mg
EUR 2465

Anti-Human Galectin-1 Azide Free

MBS335797-02mg 0.2mg
EUR 290

Anti-Human Galectin-1 Azide Free

MBS335797-05mg 0.5mg
EUR 555

Anti-Human Galectin-1 Azide Free

MBS335797-5x05mg 5x0.5mg
EUR 2465

Human Galectin-1 ELISA Kit

EK5323 96 tests
EUR 599

Human Galectin-1 ELISA Kit

IHULGALS1KT each
EUR 702
Description: Human Galectin-1 ELISA Kit

Human Galectin-1 ELISA Kit

MBS765403-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Galectin-1 ELISA Kit

MBS765403-48StripWells 48-Strip-Wells
EUR 340

Human Galectin-1 ELISA Kit

MBS765403-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Galectin-1 ELISA Kit

MBS765403-96StripWells 96-Strip-Wells
EUR 455

Human Galectin-1 ELISA Kit

MBS8414441-1Kit 1Kit
EUR 755

Human Galectin-1 ELISA Kit

MBS8414441-5x1Kit 5x1Kit
EUR 3455

Human Galectin-1 ELISA Kit

MBS2883188-10x96StripWells 10x96-Strip-Wells
EUR 3290

Human Galectin-1 ELISA Kit

MBS2883188-48StripWells 48-Strip-Wells
EUR 340

Human Galectin-1 ELISA Kit

MBS2883188-5x96StripWells 5x96-Strip-Wells
EUR 1800

Human Galectin-1 ELISA Kit

MBS2883188-96StripWells 96-Strip-Wells
EUR 435

Recombinant Human Galectin 1

MBS7609301-005mg 0.05mg
EUR 345

Recombinant Human Galectin 1

MBS7609301-02mg 0.2mg
EUR 635

Recombinant Human Galectin 1

MBS7609301-1mg 1mg
EUR 1800

Recombinant Human Galectin 1

MBS7609301-5x1mg 5x1mg
EUR 6955

Human Galectin-1 (LEG1) Protein

abx690252-100g 100 µg
EUR 837.5

Human Galectin-1 (LEG1) Protein

abx690252-20g 20 µg
EUR 350

Human Galectin 1 CLIA Kit

MBS8425460-INQUIRE INQUIRE Ask for price

Human Galectin 1 (GAL1) ELISA

KT-15605 96 tests
EUR 952

Human Galectin-1 (LGALS1) Protein

abx670211-50ug 50 ug
EUR 661.2

Galectin-1, 1-135aa, Human, E Coli

MBS203386-002mg 0.02mg
EUR 190

Galectin-1, 1-135aa, Human, E Coli

MBS203386-01mg 0.1mg
EUR 280

Galectin-1, 1-135aa, Human, E Coli

MBS203386-05mg 0.5mg
EUR 570

Galectin-1, 1-135aa, Human, E Coli

MBS203386-5x05mg 5x0.5mg
EUR 2325

Mouse Monoclonal anti-human Galectin-1

hAP-1228 50ug
EUR 400

Sheep Polyclonal anti-Human Galectin-1

hAP-5905 50ug
EUR 400

Human Galectin 1 ELISA kit

E01A4669 96T
EUR 700
Description: ELISA

Human Galectin 1 ELISA kit

E01G0038-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA kit

E01G0038-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA kit

E01G0038-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA Kit

MBS029650-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Galectin 1 ELISA Kit

MBS029650-48StripWells 48-Strip-Wells
EUR 550

Human Galectin 1 ELISA Kit

MBS029650-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Galectin 1 ELISA Kit

MBS029650-96StripWells 96-Strip-Wells
EUR 765

Human Galectin 1 ELISA Kit

IHUGAL1KT each
EUR 667
Description: Human Galectin 1 ELISA Kit

Human Galectin 1 ELISA Kit

MBS721030-48StripWellsCompetitive 48-Strip-Wells-(Competitive)
EUR 485

Human Galectin 1 ELISA Kit

MBS721030-48StripWellsSandwich 48-Strip-Wells-(Sandwich)
EUR 485

Human Galectin 1 ELISA Kit

MBS721030-5x96StripWellsCompetitive 5x96-Strip-Wells-(Competitive)
EUR 3020

Human Galectin 1 ELISA Kit

MBS721030-96StripWellsCompetitive 96-Strip-Wells-(Competitive)
EUR 690

Human Galectin 1 ELISA Kit

MBS721030-96StripWellsSandwich 96-Strip-Wells-(Sandwich)
EUR 690

Human Galectin 1 ELISA Kit

MBS8248373-5x96Tests 5x96Tests
EUR 2880

Human Galectin 1 ELISA Kit

MBS8248373-96Tests 96Tests
EUR 645

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-48StripWells 48-Strip-Wells
EUR 550

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-96StripWells 96-Strip-Wells
EUR 765

Human Galectin-3

MBS691554-001mg 0.01mg
EUR 300

Human Galectin-3

MBS691554-005mg 0.05mg
EUR 450

Human Galectin-3

MBS691554-5x005mg 5x0.05mg
EUR 1725

Phage Displayed Domain Antibodies (dAb) for Detection of Allergenic Pistachio Proteins in Foods

Pistachio nuts (Pistacia vera) have been consumed by past and present-day civilizations because of their organoleptic characteristics and potential health benefits. However, they can also produce moderate to severe IgE-mediated reactions in allergic individuals. In this work, we report the isolation of the first recombinant antibodies against pistachio nut, produced without animal immunization, to be used in immunoassays for detection of allergenic pistachio in food products.
Several phage display biopanning strategies were evaluated to screen the human-based domain antibody library (dAb) in search for pistachio-specific probes. The clone producing the PVF4 phage-dAb was finally selected, and it does not cross-react with cashew despite the phylogenetic proximity with pistachio.
Western blot and matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-TOF/TOF) analysis demonstrated that this clone recognised a unique band of ∼22 kDa related to the basic subunit of pistachio 11S globulin (allergen Pis v 2).
The PVF4 phage-dAb allowed detection of pistachio in a food matrix with a limit of detection (LOD) of 3983 mg kg-1 in an indirect phage-enzyme-linked immunosorbent assay (ELISA). The ELISA method developed was used to assess applicability of the PVF4 phage-dAb for analysis of 77 commercial food products.

MOUSE ANTI HUMAN CD163

MBS212351-02mg 0.2mg
EUR 550

MOUSE ANTI HUMAN CD163

MBS212351-5x02mg 5x0.2mg
EUR 2295

human anti-human CD163 mAb

E4A09C49 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse Anti Human CD163: RPE

MBS225636-100Tests 100Tests
EUR 520

Mouse Anti Human CD163: RPE

MBS225636-5x100Tests 5x100Tests
EUR 2160

MOUSE ANTI HUMAN CD163: FITC

MBS225948-01mg 0.1mg
EUR 435

MOUSE ANTI HUMAN CD163: FITC

MBS225948-5x01mg 5x0.1mg
EUR 1785

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48Tests 48 Tests Ask for price

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96Tests 96 Tests
EUR 388

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48T 48T
EUR 346.8

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96T 96T
EUR 559.2

Human CD163 antigen(CD163)ISA kit

QY-E05066 96T
EUR 433.2

human CD163 antigen,CD163 LISA kit

201-12-0247 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

human CD163 antigen,CD163 ELISA kit

YLA0098HU-48T 48T Ask for price

human CD163 antigen,CD163 ELISA kit

YLA0098HU-96T 96T Ask for price

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-1096T 10*96T
EUR 4122

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-48wells 48 wells
EUR 300

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-596T 5*96T
EUR 2061

Human CD163 antigen,CD163 ELISA KIT

E0246Hu-96wells 96 wells
EUR 458

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-48StripWells 48-Strip-Wells
EUR 550

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human CD163 Antigen (CD163) ELISA Kit

MBS9353075-96StripWells 96-Strip-Wells
EUR 765

Human CD163 antigen, CD163 ELISA Kit

MBS165165-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human CD163 antigen, CD163 ELISA Kit

MBS165165-48StripWells 48-Strip-Wells
EUR 285

Human CD163 antigen, CD163 ELISA Kit

MBS165165-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human CD163 antigen, CD163 ELISA Kit

MBS165165-96StripWells 96-Strip-Wells
EUR 425

Human CD163 Antigen, CD163 GENLISA ELISA

KBH0246 1 x 96 wells
EUR 286

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47162MH 25 µg
EUR 446.4

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47163MH 0.2 mg
EUR 1057.2

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-100Tests 100Tests
EUR 520

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-25Tests 25Tests
EUR 275

Mouse Anti Human CD163, APC Conjugated mAb

MBS9431893-5x100Tests 5x100Tests
EUR 2195

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 2

SC308167 10 µg Ask for price

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 1

SC117495 10 µg Ask for price

PE anti-human CD163

E16FHP163-025 25 tests
EUR 433.33
Description: Available in various conjugation types.

PE anti-human CD163

E16FHP163-100 100 tests
EUR 953.33
Description: Available in various conjugation types.

Anti-Human CD163 PE

MBS696987-100Tests 100Tests
EUR 415

Anti-Human CD163 PE

MBS696987-25Tests 25Tests
EUR 225

Anti-Human CD163 PE

MBS696987-5x100Tests 5x100Tests
EUR 1820

Anti-Human CD163 Antibody

101-M291 100 µg
EUR 399
Description: CD163, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. Two alternatively spliced cytoplasmic variants of human CD163 exist. A soluble form of CD163 can also be released by metalloproteinase-mediated shedding of the extracellular domain. CD163 mediates the endocytosis of haptoglobin-hemoglobin complexes.

APC anti-human CD163

E16FHA163-025 25 tests
EUR 520
Description: Available in various conjugation types.

APC anti-human CD163

E16FHA163-100 100 tests
EUR 1191.67
Description: Available in various conjugation types.

Anti-Human CD163 APC

MBS696989-100Tests 100Tests
EUR 480

Anti-Human CD163 APC

MBS696989-25Tests 25Tests
EUR 245

Anti-Human CD163 APC

MBS696989-5x100Tests 5x100Tests
EUR 2115

APC anti-human CD163

MBS9459445-100Tests 100Tests
EUR 655

APC anti-human CD163

MBS9459445-25Tests 25Tests
EUR 355

APC anti-human CD163

MBS9459445-5x100Tests 5x100Tests
EUR 2790

FITC anti-human CD163

E16FHF163-025 25 tests
EUR 520
Description: Available in various conjugation types.

FITC anti-human CD163

E16FHF163-100 100 tests
EUR 1191.67
Description: Available in various conjugation types.

Biotin anti-human CD163

E16FHB163-025U 25 μg
EUR 346.67
Description: Available in various conjugation types.

Biotin anti-human CD163

E16FHB163-100U 100 μg
EUR 780
Description: Available in various conjugation types.

Purified anti-human CD163

E16FHU163-100U 100 μg
EUR 433.33
Description: Available in various conjugation types.

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 2

RG212754 10 µg Ask for price

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 1

RG208557 10 µg Ask for price

Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

IRBAHUCD163ABCC3C100UL each
EUR 496
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

Recombinant Human CD163/CD163 Protein, His Tag

E40KMH346 20ug
EUR 495

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 1

RC208557 10 µg Ask for price

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 2

RC212754 10 µg Ask for price

Human CD163 Protein

E40KMPH6242 20ug
EUR 495

Recombinant Human CD163

MBS147285-0001mg 0.001mg
EUR 240

Recombinant Human CD163

MBS147285-0005mg 0.005mg
EUR 310

Recombinant Human CD163

MBS147285-005mg 0.05mg
EUR 1360

Recombinant Human CD163

MBS147285-5x005mg 5x0.05mg
EUR 5800

CD163 siRNA (Human)

MBS8229683-15nmol 15nmol
EUR 405

CD163 siRNA (Human)

MBS8229683-30nmol 30nmol
EUR 565

CD163 siRNA (Human)

MBS8229683-5x30nmol 5x30nmol
EUR 2450

Anti-Human CD163 Antibody (M130)

MBS1564482-01mg 0.1mg
EUR 340

Anti-Human CD163 Antibody (M130)

MBS1564482-5x01mg 5x0.1mg
EUR 1235

Anti-Human CD163 Antibody (AB101)

MBS1570008-01mg 0.1mg
EUR 405

Anti-Human CD163 Antibody (AB101)

MBS1570008-5x01mg 5x0.1mg
EUR 1520

PE-Cy7 anti-human CD163

E16FHN163-025 25 tests
EUR 650
Description: Available in various conjugation types.

PE-Cy7 anti-human CD163

E16FHN163-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163

E16FHO163-025 25 tests
EUR 650
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163

E16FHO163-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163

E16FHS163-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163

E16FHS163-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

Anti-Human CD163 PE-Cyanine7

MBS696988-100Tests 100Tests
EUR 505

Anti-Human CD163 PE-Cyanine7

MBS696988-25Tests 25Tests
EUR 270

Anti-Human CD163 PE-Cyanine7

MBS696988-5x100Tests 5x100Tests
EUR 2220

Mouse Monoclonal anti-human CD163

hAP-0161 100ug
EUR 250

Mouse Monoclonal anti-human CD163

hAP-0161A 50ug
EUR 400

Human CD163, Fc Tag

E24PHA282 50 μg
EUR 250

Human CD163, His Tag

E24PHA281 50 μg
EUR 250

Human CD163 ELISA Kit

EK5296 96 tests
EUR 599

Human CD163 ELISA Kit

ELI-05603h 96tests
EUR 696

Human CD163 ELISA Kit

ELA-E1726h 96tests
EUR 696

Human CD163 ELISA Kit

GWB-SKR207 96 Tests Ask for price

Human CD163 ELISA Kit

LF-EK50890 1×96T
EUR 777.6

Human CD163 ELISA Kit

MBS824474-5x96Tests 5x96Tests
EUR 2880

Human CD163 ELISA Kit

MBS824474-96Tests 96Tests
EUR 645

Human CD163 ELISA Kit

MBS3800092-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human CD163 ELISA Kit

MBS3800092-48StripWells 48-Strip-Wells
EUR 550

Human CD163 ELISA Kit

MBS3800092-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human CD163 ELISA Kit

MBS3800092-96StripWells 96-Strip-Wells
EUR 765

Human CD163 shRNA Plasmid

20-abx956176
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human CD163 Protein Lysate

MBS138999-002mg 0.02mg
EUR 365

Human CD163 Protein Lysate

MBS138999-5x002mg 5x0.02mg
EUR 1410

Recombinant Human CD163 Protein

RP02295 500μg
EUR 1625

Human CD163 Recombinant Protein

PROTQ86VB7 10ug
EUR 350
Description: Human CD163 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 42-1050aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

CD163 (Human) ELISA Kit

EKA52023-5x96T 5x96T Ask for price

CD163 (Human) ELISA Kit

EKA52023-96T 96T
EUR 446.9

Human CellExp? CD163, Human recombinant

9226-10 each
EUR 366

Human CellExp? CD163, Human recombinant

9226-50 each
EUR 927.6

anti- CD163/M130 Antibody

FNab09771 100µg
EUR 658.5
Description: Antibody raised against CD163/M130 

Mouse Monoclonal anti-Human CD163 Antibody

xAP-0134 100ug
EUR 280

Mouse Monoclonal anti-Human CD163 Antibody

xAP-0135 100ug
EUR 280

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