The Role of IgG Subclass in Antibody-Mediated

The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae
- Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
- However, the characteristics by which these antibodies (Abs) function, such as the role of antibody subclass, must be determined before such modalities can be carried from the bench to the bedside. We performed a subclass switch on anticapsular monoclonal murine IgG3 (mIgG3) hybridomas and identified and purified a murine IgG1 (mIgG1) hybridoma line through sib selection. We then compared the ability of the mIgG1 and mIgG3 antibodies to control CR-Kp sequence type 258 (ST258) infection both in vitro and in vivo.
- We found by enzyme-limited immunosorbent assay (ELISA) and flow cytometry that mIgG3 has superior binding to the CR-Kp capsular polysaccharide (CPS) and superior agglutinating ability compared to mIgG1 The mIgG3 also, predictably, had better complement-mediated serum bactericidal activity than the mIgG1 and also promoted neutrophil-mediated killing at concentrations lower than that of the mIgG1 In contrast, the mIgG1 had marginally better activity in improving macrophage-mediated phagocytosis.
- Comparing their activities in a pulmonary infection model with wild-type as well as neutropenic mice, both antibodies reduced organ burden in a nonlethal challenge, regardless of neutrophil status, with mIgG1 having the highest overall burden reduction in both scenarios.
- However, at a lethal inoculum, both antibodies showed reduced efficacy in neutropenic mice, with mIgG3 retaining the most activity. These findings suggest the viability of monoclonal Ab adjunctive therapy in neutropenic patients that cannot mount their own immune response, while also providing some insight into the relative contributions of immune mediators in CR-Kp protection.IMPORTANCE Carbapenem-resistant Klebsiella pneumoniae is an urgent public health threat that causes life-threatening infections in immunocompromised hosts.
- Its resistance to nearly all antibiotics necessitates novel strategies to treat it, including the use of monoclonal antibodies. Monoclonal antibodies are emerging as important adjuncts to traditional pharmaceuticals, and studying how they protect against specific bacteria such as Klebsiella pneumoniae is crucial to their development as effective therapies.
- Antibody subclass is often overlooked but is a major factor in how an antibody interacts with other mediators of immunity. This paper is the first to examine how the subclass of anticapsular monoclonal antibodies can affect efficacy against CR-Kp Additionally, this work sheds light on the viability of monoclonal antibody therapy in neutropenic patients, who are most vulnerable to CR-Kp infection.

enviroshieldproducts
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1-CSB-EP012882HU | Cusabio |
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Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
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1-CSB-EP012882HUb1 | Cusabio |
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Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
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YLA0216HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
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YLA0216HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
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KH040 | Sceti | each | EUR 778.8 |
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. |
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7-00427 | CHI Scientific | 10µg | Ask for price |
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7-00428 | CHI Scientific | 50µg | Ask for price |
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7-00429 | CHI Scientific | 1mg | Ask for price |
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20-abx066725 | Abbexa |
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4648-10 | Biovision | each | EUR 170.4 |
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4648-1000 | Biovision | each | EUR 1977.6 |
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4648-50 | Biovision | each | EUR 314.4 |
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E01G0038-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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E01G0038-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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E01G0038-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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abx670211-50ug | Abbexa | 50 ug | EUR 661.2 |
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STJ15100163 | St John's Laboratory | 250 µg | EUR 403.2 |
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation |
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FNab03316 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Galectin-3 |
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FNab03317 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against Galectin-3 |
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FNab03318 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Galectin-7 |
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EK5323 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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3596-100 | Biovision | each | EUR 379.2 |
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3596-30T | Biovision | each | EUR 175.2 |
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R34524-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Lectin, galactose binding, soluble 1; Lgals1 |
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R34565-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Lgals1 |
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33159-05111 | AssayPro | 150 ug | EUR 313.2 |
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33165-05111 | AssayPro | 150 ug | EUR 313.2 |
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33175-05111 | AssayPro | 150 ug | EUR 313.2 |
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32652-05111 | AssayPro | 150 ug | EUR 313.2 |
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PROTP09382-1 | BosterBio | 50ug | EUR 380.4 |
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues. |
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RP00007 | Abclonal | 20 μg | EUR 208.8 |
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20-abx190336 | Abbexa |
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abx196676-96tests | Abbexa | 96 tests | EUR 990 |
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SCA321Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6777.36 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. |
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SCA321Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 663.31 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. |
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SCA321Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 896.16 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. |
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SCA321Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3672.72 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. |
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4-SCA321Hu | Cloud-Clone |
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Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1)Serum, plasma and other biological fluids |
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CSB-EL012882HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1 (LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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1-CSB-EL012882HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1(LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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E01G0448-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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E01G0448-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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E01G0448-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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30005-05121 | AssayPro | 150 ug | EUR 442.8 |
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201-12-3227 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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DLR-GAL1-Hu-48T | DL Develop | 48T | EUR 574.8 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-GAL1-Hu-96T | DL Develop | 96T | EUR 745.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RK01436 | Abclonal | 96 Tests | EUR 625.2 |
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RDR-GAL1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
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RDR-GAL1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
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QY-E04196 | Qayee Biotechnology | 96T | EUR 433.2 |
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RD-GAL1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 573.6 |
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RD-GAL1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 794.4 |
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SEA321Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4091.29 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. |
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SEA321Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 442.1 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. |
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SEA321Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 580.15 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. |
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SEA321Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2250.68 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. |
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4-SEA321Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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YLA3564HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
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YLA3564HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
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FNab03310 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Galectin 2 |
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FNab03311 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Galectin 4 |
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FNab03312 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Galectin 8 |
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FNab03313 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Galectin 9 |
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4-PAA321Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Galectin 1 (GAL1) |
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70R-GR002 | Fitzgerald | 100 ug | EUR 571.2 |
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody |
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70R-11939 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal Galectin 1 antibody |
Phage Displayed Domain Antibodies (dAb) for Detection of Allergenic Pistachio Proteins in Foods
Pistachio nuts (Pistacia vera) have been consumed by past and present-day civilizations because of their organoleptic characteristics and potential health benefits. However, they can also produce moderate to severe IgE-mediated reactions in allergic individuals. In this work, we report the isolation of the first recombinant antibodies against pistachio nut, produced without animal immunization, to be used in immunoassays for detection of allergenic pistachio in food products.
Several phage display biopanning strategies were evaluated to screen the human-based domain antibody library (dAb) in search for pistachio-specific probes. The clone producing the PVF4 phage-dAb was finally selected, and it does not cross-react with cashew despite the phylogenetic proximity with pistachio.
Western blot and matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-TOF/TOF) analysis demonstrated that this clone recognised a unique band of ∼22 kDa related to the basic subunit of pistachio 11S globulin (allergen Pis v 2).
The PVF4 phage-dAb allowed detection of pistachio in a food matrix with a limit of detection (LOD) of 3983 mg kg-1 in an indirect phage-enzyme-linked immunosorbent assay (ELISA). The ELISA method developed was used to assess applicability of the PVF4 phage-dAb for analysis of 77 commercial food products.
![]() Human CD163 antigen(CD163)ISA kit |
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QY-E05066 | Qayee Biotechnology | 96T | EUR 433.2 |
![]() human CD163 antigen,CD163 LISA kit |
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201-12-0247 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
![]() human CD163 antigen,CD163 ELISA kit |
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YLA0098HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
![]() human CD163 antigen,CD163 ELISA kit |
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YLA0098HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
![]() Mouse Anti Human Cd163 Monoclonal Antibody |
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CABT-47162MH | Creative Diagnostics | 25 µg | EUR 446.4 |
![]() Mouse Anti Human Cd163 Monoclonal Antibody |
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CABT-47163MH | Creative Diagnostics | 0.2 mg | EUR 1057.2 |
![]() anti- CD163/M130 Antibody |
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FNab09771 | FN Test | 100µg | EUR 658.5 |
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Description: Antibody raised against CD163/M130 |
![]() Anti-Hu CD163 PE |
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1P-645-T025 | ExBio | 25 tests | EUR 168 |
![]() Anti-Hu CD163 PE |
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1P-645-T100 | ExBio | 100 tests | EUR 288 |
![]() Anti-Hu CD163 APC |
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1A-645-T025 | ExBio | 25 tests | EUR 168 |
![]() Anti-Hu CD163 APC |
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1A-645-T100 | ExBio | 100 tests | EUR 288 |
![]() Anti-Hu CD163 Purified |
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11-645-C025 | ExBio | 0.025 mg | EUR 118.8 |
![]() Anti-Hu CD163 Purified |
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11-645-C100 | ExBio | 0.1 mg | EUR 189.6 |
![]() Human CD163 ELISA Kit |
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LF-EK50890 | Abfrontier | 1×96T | EUR 777.6 |
![]() Human CD163 ELISA Kit |
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ELA-E1726h | Lifescience Market | 96 Tests | EUR 988.8 |
![]() Human CD163 shRNA Plasmid |
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20-abx956176 | Abbexa |
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![]() Anti-Hu CD163 PE-Cy7 |
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T7-645-T025 | ExBio | 25 tests | EUR 184.8 |
![]() Anti-Hu CD163 PE-Cy7 |
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T7-645-T100 | ExBio | 100 tests | EUR 321.6 |
![]() Anti-Hu CD163 PerCP-Cy5.5 |
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T9-645-T025 | ExBio | 25 tests | EUR 235.2 |
![]() Anti-Hu CD163 PerCP-Cy5.5 |
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T9-645-T100 | ExBio | 100 tests | EUR 422.4 |
![]() PE Anti-human CD163 Antibody *GHI/61* |
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116301K0 | AAT Bioquest | 25 tests | EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PE Anti-human CD163 Antibody *GHI/61* |
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116301K1 | AAT Bioquest | 100 tests | EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PE Anti-human CD163 Antibody *GHI/61* |
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116301K2 | AAT Bioquest | 500 tests | EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() APC Anti-human CD163 Antibody *GHI/61* |
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116301B0 | AAT Bioquest | 25 tests | EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() APC Anti-human CD163 Antibody *GHI/61* |
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116301B1 | AAT Bioquest | 100 tests | EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() APC Anti-human CD163 Antibody *GHI/61* |
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116301B2 | AAT Bioquest | 500 tests | EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() FITC Anti-human CD163 Antibody *GHI/61* |
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116301G0 | AAT Bioquest | 100 tests | EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() FITC Anti-human CD163 Antibody *GHI/61* |
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116301G1 | AAT Bioquest | 500 tests | EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() TRITC Anti-human CD163 Antibody *GHI/61* |
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116301H0 | AAT Bioquest | 100 tests | EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() TRITC Anti-human CD163 Antibody *GHI/61* |
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116301H1 | AAT Bioquest | 500 tests | EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PerCP Anti-human CD163 Antibody *GHI/61* |
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116301S0 | AAT Bioquest | 25 tests | EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PerCP Anti-human CD163 Antibody *GHI/61* |
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116301S1 | AAT Bioquest | 100 tests | EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PerCP Anti-human CD163 Antibody *GHI/61* |
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116301S2 | AAT Bioquest | 500 tests | EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PacBlue Anti-human CD163 Antibody *GHI/61* |
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116301I0 | AAT Bioquest | 100 tests | EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PacBlue Anti-human CD163 Antibody *GHI/61* |
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116301I1 | AAT Bioquest | 500 tests | EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() Purified Anti-human CD163 Antibody *GHI/61* |
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11630000 | AAT Bioquest | 100 ug | EUR 365 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PacOrange Anti-human CD163 Antibody *GHI/61* |
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116301J0 | AAT Bioquest | 100 tests | EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() PacOrange Anti-human CD163 Antibody *GHI/61* |
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116301J1 | AAT Bioquest | 500 tests | EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
![]() Canine CD163 antigen(CD163 LISA kit |
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GA-E0062CN-48T | GenAsia Biotech | 48T | EUR 482.4 |
![]() Canine CD163 antigen(CD163 LISA kit |
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GA-E0062CN-96T | GenAsia Biotech | 96T | EUR 820.8 |
![]() Human CellExp? CD163, Human recombinant |
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9226-10 | Biovision | each | EUR 366 |
![]() Human CellExp? CD163, Human recombinant |
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9226-50 | Biovision | each | EUR 927.6 |
![]() Porcine CD163 antigen,CD163 LISA kit |
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GA-E0045PC-48T | GenAsia Biotech | 48T | EUR 436.8 |
![]() Porcine CD163 antigen,CD163 LISA kit |
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GA-E0045PC-96T | GenAsia Biotech | 96T | EUR 708 |
![]() Porcine CD163 antigen,CD163 LISA kit |
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YLA0139PO-48T | Shanghai YL Biotech | 48T | EUR 502.5 |
![]() Porcine CD163 antigen,CD163 LISA kit |
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YLA0139PO-96T | Shanghai YL Biotech | 96T | EUR 618.75 |
![]() ELISA kit for Human CD163 |
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EK5296 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD163 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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49553-100ul | SAB | 100ul | EUR 399.6 |
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49553-50ul | SAB | 50ul | EUR 286.8 |
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10R-CD163aRT | Fitzgerald | 250 ug | EUR 859.2 |
Description: Mouse monoclonal CD163 antibody |
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10R-6496 | Fitzgerald | 100 ug | EUR 243.6 |
Description: Mouse monoclonal CD163 antibody |
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ABD8235 | Lifescience Market | 100 ug | EUR 525.6 |
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37157-100ul | SAB | 100ul | EUR 302.4 |
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1-CSB-PA650452LA01MO | Cusabio |
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Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
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20-abx242956 | Abbexa |
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1-CSB-PA969205 | Cusabio |
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Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100 |
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DF8235 | Affbiotech | 200ul | EUR 420 |
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1-CSB-PA801238LA01HU | Cusabio |
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Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
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F50316-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
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F50316-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
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RQ4259 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
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R30973 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptor for the hemoglobin-haptoglobincomplex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the CD163 gene to chromosome 12p13.3. Specific CD163-mediated endocytosis of haptoglobin-hemoglobin complexes was measurable in cells transfected with CD163 cDNA and in CD163-expressing myelomonocytic lymphoma cells.CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by anti-CD163 antibodies. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
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R30974 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Cluster of Differentiation 163, also known as Hemoglobin scavenger receptor, is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptorfor the hemoglobin-haptoglobin complex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the gene to chromosome 12p13.3. CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by CD163 antibody. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
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V8227-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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V8227-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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V8227SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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V8415-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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V8415-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |